Gaia Andreoletti

Two weeks have gone so fast! Thank you all for your amazing questions

Favourite Thing: When after weeks of experiments/failures I am finally able to make things work!



2008-20011 BSc at University of Pavia (Italy), 2011-2012 Msc at Birkbeck College, Univerity of London


BSc and MSc

Work History:

Current Job:

Ph.D. Student


University of Southampton

My STFC facility

Me and my work

I look for “bad” genetic mutations in children presenting with inflammatory bowel disease with the use of a super-computer

I am Italian student currently conducting my Ph.D. in the Genomics Informatics group at University of Southampton.

I am part of a large and multidisciplinary team of the Southampton paediatric Inflammatory bowel disease research study. The team is composed of nurses, doctors, scientists and laboratory staff. We now have over 1000 people recruited in the study, including children and parents.

The aim of the study is to improve the diagnosis, treatment and long-term care for patients diagnosed with paediatric inflammatory bowel disease.

My Ph.D. focuses on the analysis of the gene mutations within the DNA of the children with this stomach condition.

DNA is a molecule of a shape of a twisted ladder. DNA acts as a blueprint or recipe for all living organism. The ladder is composed of four letters (A, G, T and C) that can be read like a book. Human DNA contains about 3 billion pairs of these bases. Each piece of information is carried on a different section of the DNA.

These sections are called genes.

Genes are found in the cells that make up our bodies but are so tiny that they are invisible without special microscopes. Changes within genes can occur (named mutations) and these changes can be either good, e.g resulting in different eyes colour, height or foot size, or can be bad which can cause disease and other problems. Every individual is different from each other and carries different and specific bad and good mutations.

I am really interested in identifying the specific mutations that causes the person disease. I am able to do so by simply taking a bit of the patient’s blood and extracting the genes out of it. I am  then able to read the genes by using a cutting edge technology called “next generation sequencing technology“ which allows to fully examine every mutations a person carries using a super powerful computer named Iridis. Every person carries approximately 25 000 mutations (that is a lot!) therefore the use of a supercomputer is really necessary!

My Typical Day

Sitting in from of my desk coding and analysing lots of data

Sitting behind my computer!

I get to work around 9/9:30 am and i start answering emails, work on most pressing project and meeting with my supervisor.

12:00 – 1:00pm: lunch

The rest of the day is usually the same as in the morning.

5:30/6:00 pm: leave for home

That’s pretty much it.

We have weekly group meetings and meetings for our entire Institute every few months.

As you might not be aware, many tasks take several hours to finish on the supercomputer so when multitasking I submit some jobs for one project and move to development for another.

There is always  time that includes reading papers, source code to better understand technologies changes and for CAKE!

What I'd do with the money

I would donate the money to the charity ‘Kids with guts’ to develop a new genetic outreach activity

My Interview

How would you describe yourself in 3 words?

Collegiate, friendly, ambitious

Who is your favourite singer or band?

Coldplay, Tracy Chapman and Jovanotti (Italian singer)

What's your favourite food?

Risotto, pasta and pizza (as a truly Italian)

What is the most fun thing you've done?

The road trip around Europe with my friends

What did you want to be after you left school?

Medical doctor

Were you ever in trouble at school?

Sometimes, when i wasn’t really prepared for exams in class

What was your favourite subject at school?

Biology and Literature

What's the best thing you've done as a scientist?

To have found the cause of a disease in a patient and knowing that this discovery helped doctors to tailor her treatment plans

What or who inspired you to become a scientist?

Rita Levi Montalcini – and also because I had good grades in Biology Class

If you weren't a scientist, what would you be?


If you had 3 wishes for yourself what would they be? - be honest!

Travelling around the word, health and being the next winner of Masterchef

Tell us a joke.

Why won’t the elephant use the computer?….He’s afraid of the mouse!

Other stuff

Work photos:

This is me and a colleague of mine looking at the DNA of the patients of the research study. Lots of colors and lines to distinguish each letter of the DNA

myimage1 myimage2